New Zealand Salvia divinorum - Our Current Wordpress Web Page: HERE
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**Increase in N.Z Post Delivery Rates** July 2023
Due to inflationary pressures, new Rates are as follows:
Economy Rate, tracked @ $8.
Courier Rate, tracked @ $10. (*Fastest Delivery)
Rural Delivery Rate @ plus+ $5.50
Due to N.Z Post price increases, you might like to consider *Parcel Collect to avoid the extra Rural Delivery Costs for some Customers.
Due to ongoing cost increases, ALL Salvia Specials, *Excluding our 5x Extract Deals & 5x Combo Specials, are Suspended until further Notice.
*R.18 N.Z Customers Only. Proof of Age Required.
If you do not Verify Age, we will not process your Order.
Payment via Online Banking. N.Z Post track & trace.
Ordering Process - Summary of - HERE
F.A.Q - Re prices/products/purchase - HERE
*Price List & Specials - HERE
*NorthlandSalvia Lite: view Previews of all our Primary content: HERE
*Salvia: Natural Leaves, Extract & Liquid Extract: HERE
Cancer Research & Cannabinoids - HERE
*Coronavirus Disease - Potential Use of Cannabinoids to Treat Acute Respiratory Distress Syndrome and Cytokine Storm Associated with Covid19 - HERE
Contact: northlandsalvia@gmail.com
Buy Online CB.2RA Cannabinoid Oil Tincture VG Juice & Balm New Zealand N.Z
CB.2RA Site Content Links:
CB2R.A Cannabinoid Oil Tincture VG Juice HERE
CB2R.A Cannabinoid Balm Cannabinoids + Terpenes HERE
CB.2 K.O.R Double Action Oil Tincture VG Juice. Salvia + Cannabinoids + Terpenes HERE
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Vaping CB.2RA & CB.2-K.O.R Cannabinoid Oil HERE
Cannabinoids as a potential treatment for Addiction. HERE
β‐Caryophyllene (BCP), inhibits nicotine taking and nicotine seeking HERE
Corona Virus: Potential Use of Cannabinoids to Treat Acute Respiratory Distress Syndrome and Cytokine Storm Associated with Coronavirus Disease. HERE
Misleading Marketing of Hemp Seed Oil as Cannabinoid Oil in New Zealand - Spot the Impostor! HERE
CB.2 Cannabinoid Research Links HERE
Cannabinoids & Cancer Research Links HERE
*All our CB.2RA & CB.2-K.O.R products are 30x strength extracts, i.e, 30 times stronger than the naturally occurring constituents, contained in the Plant source.
" Hi, I have ordered from you in the past. Is it possible to get another CB2R.A oil. It worked really well. I think the CB2R.A oil will be good for me. Can you please help?"
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There are many commercially available
Cannabis preparations rich in β-caryophyllene
(BCP), including:
Bedrocan®, Sativex®, Marinol®, Bedrobinol®, Namisol®, Arvisol®, Fenoxidol™,
Epidiolex® etc. Hebaallah Mamdouh Hashiesh et al, 2021
beta Caryophyllene (BCP) is a major component in Cannabis & some non Cannabis plants, & is classified as a dietary cannabinoid.
BCP, & its status as a dietary Cannabinoid, DOES NOT have the Legal & Licensing restrictions of Cannabis.
See Link: Terpene Profile Caryophyllene (Tilray)
The phytocannabinoid caryophyllene, also known as beta-caryophyllene or BCP, is crucial to not only the smell and taste of Cannabis, but also the medical benefits and different effects strains provide. There are over 100 known cannabinoids & terpenoids in the cannabis plant, but BCP is one of the most prominent.
C.B 2 R.A - Cannabinoid Oil also contains the primary Terpenes: Myrcene, Linalool, Pinene, Humulene, Trans-nerolidol, & more!
C.B 2 R.A - Cannabinoid Oil DOES NOT activate the CB1 Receptors, which are responsible for the 'High" associated with Cannabis sativa & indica.
C.B 2 R.A - Cannabinoid Oil DOES activate the CB2 Receptors, providing analgesic, sedative & anti inflammatory effects.
CB2R.A may assist overall health & wellbeing, by boosting the Immune System, via the E.C.S - Endocannabinoid System.
More information on the E.C.S - Endocannabinoid System & phyto-cannabinoids HERE
Cannabinoid type 2 receptor (CB2R)-mediated pharmacological activities and therapeutic potential of β-caryophyllene (BCP):
The Cannabinoid BCP beta Caryophyllene, an attractive compound for chronic pain (both inflammatory and neurogenic)
The Cannabinoid BCP beta Caryophyllene is an attractive compound for chronic pain (both inflammatory and neurogenic) due to its direct action on CB2R without creating a tolerance, as demonstrated in an animal model of neuropathic pain [30].
Remarkably, the researchers concluded that the effect of BCP became stronger during the treatment period.
This is significant considering drug tolerance after prolonged use is observed with other analgesic therapies and may require increased dosage, which may accelerate tolerance and further reduce the effects of a therapeutic substance.
BCP exerts potent anti-inflammatory effects when taken orally, which may be explained by its ability to simultaneously inhibit pathways (toll-like receptor complex CD14/TLR4/MD2) that increase the production of proinflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-⍺), reduce immune-related inflammation, and synergize the µ-opioid receptor pathways.
Preclinical models demonstrate that BCP can reduce inflammation in a variety of bacterial-caused, eosinophil-related, and neuropathic inflammatory conditions [32].
It can also enhance the effects of other pain medications like morphine, making it a promising candidate to reduce effective drug dose and therefore potential drug dependence and tolerance.
In this way, it modulates pain signaling pathways in a manner that may enhance, and not compete with, the benefits of other pain-or inflammation-relieving substances. Scott A. Johnson et al, 2020.
Our C.B 2 R.A - Cannabinoid Oil: is available as:
an Olive Oil based liquid extract.
a Vegetable Glycerine (V.G) based liquid extract.
a herbal tincture.
VG-Juice.
Introductory offer:
'Super Potentiated' High Potency, 20 ml CB2R.A Cannabinoid Oil @ $99. *plus p & p.
VG-Juice & Olive Oil CB.2RA Cannabinoid Oil.
Contact: northlandsalvia@gmail.com
Research Links:
See: Beta-caryophyllene is a dietary cannabinoid.
See: Phytocannabinoids beyond the Cannabis plant.
' At present, the only phytocannabinoid that has been discovered to also exist in plants other than Cannabis is b-caryophyllene (BCP), which is among the most abundant plant essential oil components......
b-caryophyllene, (BCP) which is also one of the most abundant secondary metabolites in Cannabis essential oil, could be considered as a true CB2 receptor-selective Cannabis constituent.'
See: Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation?
' The best studied phytochemical is β‐caryophyllene (BCP), which has been independently shown to exert numerous CB2receptor‐mediated cannabimimetic effects......'
See: β -caryophyllene and β -caryophyllene oxide - natural compounds of anticancer and analgesic properties.
" BCP is a phytocannabinoid with strong affinity to cannabinoid receptor type 2 (CB2 ) but not cannabinoid receptor type 1 (CB1 ). ...the double activity of BCP, anticancer and analgesic, as well as its beneficial influence on the efficacy of classical chemotherapeutics, is particularly valuable in oncology. "
*Full version pdf HERE
" Although the pancreatic tumor biopsies and cell lines
analyzed expressed both CB1 and CB2 cannabinoid
receptors, our findings indicate that the CB2 receptor is the one
that plays a major role in the proapoptotic effect of cannabinoids in these cells."
See: Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation
" The sesquiterpene hydrocarbon (E)-β-caryophyllene
(BCP) is one of the most studied and promising natural compounds In
recent years, modulatory and pharmacological effects of BCP have been
demonstrated in numerous organs such as liver kidney and brain. BCP has
been reported to exert therapeutic effects as antioxidant,
anti-inflammatory and anticancer. Importantly, BCP has been identified
as a fully selective agonist of CB2 cannabinoid receptors, one of the
key members of the endocannabinoid system (ECS)."
See: Beta-caryophyllene a CB2 receptor agonist, produces multiple behavioural changes relevant to anxiety & depression.
See: β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis
" (this) study represents significant implications for clinical research and strongly supports the effectiveness of BCP as a novel molecule to target in the development of effective therapeutic agents for MS. "
See: New insights in the antitumor effects of β-caryophyllene in breast cancer cells: The role of cannabinoid and adrenergic systems
" Caryophyllene (CRY) was found able to significantly inhibit the growth of MDA-MB-468 cells..... Data obtained highlight antiproliferative properties of Caryophyllene (CRY) in triple negative breast cancer, with a possible β2-adrenergic system contribution.
CRY acts partly by a CB2- activation, although other CB1/CB2 independent mechanisms appear involved. CRY also interferes with smoking-induced progression and metastatization of breast cancer cells: this effect can be approached as a chemopreventive strategy in breast oncologic patients. Present results encourage further studies on CRY as chemopreventive agent or in targeted supporting therapies for breast cancer.
See: Clinical Endocannabinoid Deficiency
" studies have provided a firmer foundation for the theory, while clinical data have also produced evidence for decreased pain, improved sleep, and other benefits to cannabinoid treatment and adjunctive lifestyle approaches affecting the ECS."
See: Therapeutic Potential of Caryophyllene: A Dietary Cannabinoid in Diabetes & Associated Complications
' Given the safe status, abundant natural occurrence, oral bioavailability, dietary use and pleiotropic properties modulating receptors and enzymes, BCP appears as a promising molecule for diabetes and its complications.'
" while all attempts are being focused on control of viral replication through development of vaccines, it is also critical to ensure that the vaccines do not trigger hyperactivation of immune response.
It is equally important to develop new anti-inflammatory therapies that can effectively block the cytokine storm seen in patients with severe form of COVID-19.
We believe that cannabinoids hold significant promise as potent anti-inflammatory agents."
Visualization of The Endocannabinoid Signaling System:
Payment via Online Banking. N.Z Post track & trace.
Contact: northlandsalvia@gmail.com
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