*All our CB.2RA & CB.2-K.O.R products are 30x strength extracts, i.e, 30 times stronger than the naturally occurring constituents, contained in the Plant source.
CB.2RA Cannabinoid Profile:
C.B 2 R.A 30x Cannabinoid Balm is a powerful, non psychoactive, all natural, plant based herbal
extract, that targets the C.B 2 Cannabinoid Receptors, & may provide
a legal alternative to 'Prescription Only'Cannabidiol (C.B.D) preparations.
beta Caryophyllene (BCP) & its status as a dietary cannabinoid.DOES NOT have the Legal restrictions & Licensing requirements of cannabis.
At present, the only phytocannabinoid that has been discovered to also exist in plants other than Cannabis is beta Caryophyllene (BCP). Gertsch et al, 2010.
The phytocannabinoid BCP
(beta Caryophyllene) has been identified as a fully selective agonist of CB2 cannabinoid
receptors, one of the key members of the endocannabinoid system (ECS).Scandiffio et al 2020.
The phytocannabinoid caryophyllene, also known as beta-caryophyllene or BCP,
is crucial to not only the smell and taste of Cannabis, but also the
medical benefits and different effects strains provide. There are over 100 known cannabinoids & terpenoids in the cannabis plant, but BCP is one of the most prominent.
BCP is a major constituent in Cannabis essential oil and shows significantcannabimimetic effects, it may also contribute to the overall effect of Cannabis preparations, including Sativex. Gertsch et al, 2008.
*All our CB.2RA & CB.2-K.O.R products are 30x strength extracts, i.e, 30 times stronger than the naturally occurring constituents, contained in the Plant source.
" Hi, I have ordered from you in the past. Is it possible to get another CB2R.A oil. It worked really well. I think the CB2R.A oil
will be good for me. Can you please help?" Kerry G. Auckland.
*Intro Special* Free CB2RA Balm OR CB.2 - K.O.R Balm with EVERY Cannabinoid Oil, tincture, VG Juice purchase! Terms & Conditions apply.
NEW!5 ml Sampler CB2R.A 30x Cannabinoid Oil, dropper bottle, @ $25. *plus p & p
'Super Potentiated' High Potency, 20 ml CB2R.A 30x Cannabinoid Oil, dropper bottle, @ $99. *plus p & p.
Become a Preferential Repeat Customerby Purchasing our 100 ml Range of CB2R.A Cannabinoid Oil, tincture, VG Juice, & Reap the Rewards of great value deals on Cannabinoids! Terms & Conditions Apply.
*Trade quantity, Bulk Purchase, Wholesale NOT Supplied.
'Super Potentiated' High Potency, 100 ml CB2R.A 30x Cannabinoid Oil @ $399. *plus p & p. FREE POST! Not incl Rural Upgrade & Priority Post. Save $
Bulk Buy & Save!500 ml & 1 Litre bottles available at Competitive Prices. Prices on enquiry. Ts & Cs Apply.
*Limited Time Offer on 30x strength, CB.2RA Cannabinoid Oil500 ml & 1 Litre Oils, Liquid Extract:
CB.2RA 500 ml @ $850. *plus p & p. ( = $170. per 100 ml )
CB.2RA 1000 ml @ $1500. *plus p & p. ( = $150. per 100 ml )
*Bulk Buy FREE Post, Economy, not incl Rural Upgrade & Courier Post.
*VG & Olive Oil 30x Liquid Extracts too.
'Super Potentiated' High Potency, 50 ml jar, CB2R.A 30x Strength Cannabinoid Balm@ $42. *plus p & p.
C.B 2 R.A 30x Cannabinoid Oil is a powerful, non psychoactive, all natural, plant based herbal
extract, that targets the C.B 2 Cannabinoid Receptors, & may provide
a legal alternative to 'Prescription Only'Cannabidiol (C.B.D) preparations, such as Tilray, Elixinol
& Sativex.
BCP, & its status as a dietary Cannabinoid, DOES NOT have the Legal & Licensing restrictions of Cannabis.
At present, the only phytocannabinoid that has been discovered to also exist in plants other than Cannabis is beta Caryophyllene (BCP). Gertsch et al, 2010.
The phytocannabinoid BCP
(beta Caryophyllene) has been identified as a fully selective agonist of CB2 cannabinoid
receptors, one of the key members of the endocannabinoid system (ECS).Scandiffio et al 2020.
β-caryophyllene (BCP) activity on human CB2 Cannabinoid Receptors, has a binding affinity (pKi) value of 155 nM with a lack of
substantial affinity for CB1R. Hashiesh et al 2021.
To compare CB2R binding, β-Caryophyllene has the highest CB2 cannabinoid activity. Cannabinol (CBN) binds to the CB2 receptors as a partial agonist with a binding affinity of CB2 Ki at 126.4 nM[9] while Delta-9-Tetrahydrocannabinol (THC) binds to the CB2 receptors as a partial agonist with an affinity of Ki at 36nM.[10]
The phytocannabinoid caryophyllene, also known as beta-caryophyllene or BCP,
is crucial to not only the smell and taste of Cannabis, but also the
medical benefits and different effects strains provide. There are over 100 known cannabinoids & terpenoids in the cannabis plant, but BCP is one of the most prominent.
BCP is a major constituent in Cannabis essential oil and shows significantcannabimimetic effects, it may also contribute to the overall effect of Cannabis preparations, including Sativex. Gertsch et al, 2008.
More information on the E.C.S - Endocannabinoid System & phyto-cannabinoids HERE
Cannabinoid type 2 receptor (CB2R)-mediated pharmacological activities and therapeutic potential of β-caryophyllene (BCP):
The Cannabinoid BCP beta Caryophyllene, an attractive compound for chronic pain (both inflammatory and
neurogenic)
The Cannabinoid BCP beta Caryophyllene
is an attractive compound for chronic pain (both inflammatory and
neurogenic) due to its direct action on CB2R without creating a
tolerance, as demonstrated in an animal model of neuropathic pain [30].
Remarkably, the researchers concluded that the effect of BCP became
stronger during the treatment period.
This is significant considering
drug tolerance after prolonged use is observed with other analgesic
therapies and may require increased dosage, which may accelerate
tolerance and further reduce the effects of a therapeutic substance.
BCP
exerts potent anti-inflammatory effects when taken orally, which may be
explained by its ability to simultaneously inhibit pathways (toll-like
receptor complex CD14/TLR4/MD2) that increase the production of
proinflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-⍺), reduce immune-related inflammation, and synergize the µ-opioid receptor pathways.
Preclinical models demonstrate that BCP can reduce inflammation in a
variety of bacterial-caused, eosinophil-related, and neuropathic
inflammatory conditions [32].
It can also
enhance the effects of other pain medications like morphine, making it a
promising candidate to reduce effective drug dose and therefore
potential drug dependence and tolerance.
In this way, it modulates pain signaling pathways in a manner that may
enhance, and not compete with, the benefits of other pain-or
inflammation-relieving substances. Scott A. Johnson et al, 2020.
an Olive Oil based liquid extract. a Vegetable Glycerine (V.G) based liquid extract. a herbal tincture. VG-Juice.
Balm50 ml jar, Natural Coconut base.
Introductory offer:
NEW!5 ml Sampler CB2R.A Cannabinoid Oil, dropper bottle, @ $25. *plus p & p
'Super Potentiated' High Potency, 20 ml CB2R.A Cannabinoid Oil @ $99. *plus p & p.
Become a Preferential Repeat Customer by Purchasing our 100 ml Range of CB2R.A
Cannabinoid Oil, tincture, VG Juice, & Reap the Rewards of great
value deals on Cannabinoids! Terms & Conditions Apply.
*Wholesale, Trade quantity, NOT Supplied.
'Super Potentiated' High Potency, 100 ml CB2R.A Cannabinoid Oil @ $399. *plus p & p delivery. FREE POST! Save $
Bulk Buy & Save!500 ml & 1 Litre bottles available at Competitive Prices. Prices on enquiry. Ts & Cs Apply.
'Super Potentiated' High Potency, 50 ml CB2R.A 30x Strength Cannabinoid Balm @ $42. *plus p & p
" (E)-BCP is the first Cannabis-derived functional CB
receptor ligand with a fundamentally different structure from the classical
cannabinoids. Thus, it represents a new type of CB2 receptor-selective agonist
that is based on an unusual cyclobutane-containing scaffold.
" BCP is a major constituent in Cannabis essential oil and shows significantcannabimimeticeffects, it may also contribute to the overall effect of Cannabis preparations, including Sativex. "
' At present, the only phytocannabinoid that has been discovered to also exist in plants other than Cannabis is b-caryophyllene (BCP), which is among the most abundant plant essential oil components......
b-caryophyllene, (BCP) which is also one of the most abundant secondary metabolites in Cannabis essential oil, could be considered as a true CB2 receptor-selective Cannabis constituent.'
" Although the pancreatic tumor biopsies and cell lines
analyzed expressed both CB1 and CB2 cannabinoid
receptors, our findings indicate that the CB2 receptor is the one
that plays a major role in the proapoptotic effect of cannabinoids in these cells."
" The sesquiterpene hydrocarbon (E)-β-caryophyllene
(BCP) is one of the most studied and promising natural compounds In
recent years, modulatory and pharmacological effects of BCP have been
demonstrated in numerous organs such as liver kidney and brain. BCP has
been reported to exert therapeutic effects as antioxidant,
anti-inflammatory and anticancer. Importantly, BCP has been identified
as a fully selective agonist of CB2 cannabinoid receptors, one of the
key members of the endocannabinoid system (ECS)."
" preclinical results suggest that CB2 receptors may
provide alternative therapeutic targets for the treatment of anxiety and
depression. The possibility that BCP may ameliorate the symptoms of these mood
disorders offers exciting prospects for future studies. "
" Caryophyllene (CRY) was found able to significantly inhibit the growth of MDA-MB-468 cells..... Data obtained highlight antiproliferative properties of Caryophyllene (CRY) in triple
negative breast cancer, with a possible β2-adrenergic system
contribution.
CRY acts partly by a CB2- activation, although other
CB1/CB2 independent mechanisms appear involved. CRY also interferes with
smoking-induced progression and metastatization of breast cancer cells:
this effect can be approached as a chemopreventive strategy in breast
oncologic patients. Present results encourage further studies on CRY as
chemopreventive agent or in targeted supporting therapies for breast
cancer.
" studies have provided a firmer foundation for the theory, while clinical
data have also produced evidence for decreased pain, improved sleep,
and other benefits to cannabinoid treatment and adjunctive lifestyle
approaches affecting the ECS."
' Given the safe status, abundant natural occurrence, oral
bioavailability, dietary use and pleiotropic properties modulating
receptors and enzymes, BCP appears as a promising molecule for diabetes
and its complications.'
" while all attempts are being focused on control of viral replication
through development of vaccines, it is also critical to ensure that the
vaccines do not trigger hyperactivation of immune response.
It is
equally important to develop new anti-inflammatory therapies that can
effectively block the cytokine storm seen in patients with severe form
of COVID-19.
We believe that cannabinoids hold significant promise as
potent anti-inflammatory agents."
Visualization of The Endocannabinoid Signaling System:
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